Anti-Smac / Diablo, clone RM271 (recombinant antibody)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
NSJ-R20288-0.1ML	100 µl		-	-	3 - 10 business days*		737.00€

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Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant Smac antibody... more

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Product information "Anti-Smac / Diablo, clone RM271 (recombinant antibody)"

Antibody in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant Smac antibody reacts to human Smac (Diablo homolog, mitochondrial). Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. [The UniProt Consortium]

Keywords:	Anti-Smac, Anti-SMAC, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second mitochondria-derived activator of caspase, Recombinant Smac Antibody / Diablo
Supplier:	NSJ Bioreagents
Supplier-Nr:	R20288

Properties

Application:	WB, IHC
Antibody Type:	Monoclonal
Clone:	RM271
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	A peptide corresponding to the C-terminus of human Smac/Diablo was used as the immunogen for this recombinant Smac antibody.
Format:	Purified