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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-N1067-25UG | 25 µg | - | - |
3 - 10 business days* |
317.00€
|
||
NSJ-N1067-100UG | 100 µg | - | - |
3 - 10 business days* |
622.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. mTOR, or Mammalian target of... more
Product information "Anti-SIN1"
0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity. Protein function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. [The UniProt Consortium]
Keywords: | Anti-MIP1, Anti-mSIN1, Anti-MAPKAP1, Anti-TORC2 subunit MAPKAP1, Anti-SAPK-interacting protein 1, Anti-Target of rapamycin complex 2 subunit MAPKAP1, Anti-Stress-activated map kinase-interacting protein 1, SIN1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | N1067 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat, dog |
Immunogen: | A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K20410 | Matching products |
UniProt ID : | Q9BPZ7 | Matching products |
Gene ID | GeneID 79109 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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