Anti-SENP3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-139A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-139A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but... more

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Product information "Anti-SENP3"

Protein function: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. [The UniProt Consortium]

Keywords:	Anti-SSP3, Anti-SENP3, EC=3.4.22.-, Anti-SUMO-1-specific protease 3, Anti-Sentrin-specific protease 3, Anti-Sentrin/SUMO-specific protease SENP3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-139A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, bovine, horse, guinea pig_10141, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, european domestic ferret, chinese hamster, small-eared galago, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A303-139A-T maps to a region between residue 1 and 50 of human SUMO1/Sentrin/SMT3 Specific Peptidase 3 using the numbering given in entry NP_056485.2 (GeneID 26168).
Format:	Antigen Affinity Purified