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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V5083SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. In aerobic respiration reactions, succinate... more
Product information "Anti-SDHA, clone SDHA/7493"
1 mg/ml in 1X PBS, BSA free, sodium azide free. In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma. Protein function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225). [The UniProt Consortium]
Keywords: | Anti-Fp, Anti-SDHA, Anti-SDH2, Anti-Flavoprotein subunit of complex II, Anti-Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, SDHA Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V5083SAF |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | SDHA/7493 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant partial protein sequence (within amino acids 450-650) from the human protein |
Format: | Purified |
Database Information
KEGG ID : | K00234 | Matching products |
UniProt ID : | P31040 | Matching products |
Gene ID | GeneID 6389 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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