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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A700-122-T | 10 µl (5+ tests) | - |
2 - 8 business days* |
172.00€
|
|||
A700-122 | 100 µl (50+ tests) | - |
2 - 8 business days* |
655.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX... more
Product information "Anti-RUNX3 Recombinant Monoclonal"
Protein function: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA- binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing. [The UniProt Consortium]
Keywords: | Anti-AML2, Anti-RUNX3, Anti-CBF-alpha-3, Anti-PEA2-alpha C, Anti-PEBP2-alpha C, Anti-Oncogene AML-2, Anti-Acute myeloid leukemia 2 protein, Anti-Core-binding factor subunit alpha-3, Anti-Runt-related transcription factor 3 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A700-122 |
Properties
Application: | WB, IP, IHC, ICC, FC |
Antibody Type: | Monoclonal |
Clone: | BLR122H |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K09279 | Matching products |
UniProt ID : | Q13761 | Matching products |
Gene ID | GeneID 864 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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