Anti-RUNX1 + RUNX2 + RUNX3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG57484.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and... more

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Product information "Anti-RUNX1 + RUNX2 + RUNX3"

Protein function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B- dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down- regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). [The UniProt Consortium]

Keywords:	Anti-AML1, Anti-RUNX1, Anti-CBF-alpha-2, Anti-PEA2-alpha B, Anti-PEBP2-alpha B, Anti-Oncogene AML-1, Anti-Acute myeloid leukemia 1 protein, Anti-Runt-related transcription factor 1, Anti-Core-binding factor subunit alpha-2
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG57484

Properties

Application:	WB, IHC (paraffin), ICC, IF, IP, FC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Synthetic peptide derived from Human RUNX1 + RUNX2 + RUNX3
MW:	51 kD
Format:	Affinity Purified