Anti-RBBP8, ID (DNA Endonuclease RBBP8, CtBP-interacting Protein, CtIP, Retinoblastoma-binding Prote

Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by ensuring both resection and intrachromosomal association of the broken ends. Promotes ATR and RPA recruitment to DSBs in S/G2 phase and facilitates the generation of ssDNA. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.