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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
R1198-34A.100 | 100 µl | - | - |
3 - 19 business days* |
796.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ras proteins are small GTP-binding proteins which, unlike the heterotrimeric G-proteins, contain... more
Product information "Anti-Ras, H (Harvey Murine Sarcoma Virus Oncogene, Ha-Ras)"
Ras proteins are small GTP-binding proteins which, unlike the heterotrimeric G-proteins, contain all GTPase and effector functions within a single polypeptide. At least three isoforms of Ras exist, Ki-Ras, Ha-Ras and N-Ras, with distinct expression patterns but similar signaling activity. Ras is palmitoylated and farnesylated at the carboxy terminus, anchoring it in the membrane. In resting cells, Ras is loaded with GDP, and is activated subsequent to growth factor stimulation of receptors, which recruit Ras Guanine nucleotide Exchange Factors to the plane of the membrane. Proximity of exchange factors to the Ras proteins causes release of GDP, and its replacement by GTP. In its GTP-bound form, Ras binds several proteins, including Raf, RalGDS and PI3 Kinase. Inactivation of Ras occurs by GTP hydrolysis, which is greatly accelerated by RasGAP or NF-1, two known Ras GTPase Activating Proteins. It is possible to assay for Ras activation by incubation of lysates with the Ras-binding domain of Raf-1, which selectively binds to Ras:GTP. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Optimal dilutions to be determined by the researcher. Positive Control: A431 cell lysate. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-HRAS, Anti-HRAS1, Anti-p21ras, Anti-H-Ras-1, Anti-c-H-ras, Anti-GTPase HRas, Anti-Transforming protein p21, Anti-GTPase HRas, N-terminally processed |
Supplier: | United States Biological |
Supplier-Nr: | R1198-34A |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 10F658 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | GST fusion protein corresponding to full length human Ha-Ras. |
Format: | Supernatant |
Database Information
KEGG ID : | K02833 | Matching products |
UniProt ID : | P01112 | Matching products |
Gene ID | GeneID 3265 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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