Anti-Prostaglandin E Synthase-1 (microsomal) (Clone 6C6)

Prostaglandin E synthase-1 (PGES-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. PGES-1 is a 16 kDa membrane associated protein with glutathione-dependent activity. The mRNA for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine as well as in A549 and HeLa cells. PGES-1 protein expression is increased in A549 cells following treatment with IL-1beta. Cayman's PGE Synthase-1 (microsomal) Monoclonal Antibody (Clone 6C6) can be used for Western blot applications. The antibody recognizes PGE Synthase-1 (microsomal) at 16 kDa from human and ovine samples.Synonyms: Membrane-Associated PGES-1, MGST1-L1, mPGE Synthase-1, mPGES-1, PIG12, Prostaglandin H/E Isomerase. Immunogen: Recombinant human mPGE synthase-1. Clone Designation: 6C6. Formulation: (Request formulation change), 300 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, after resuspension in 300 µl purified water. Host: Mouse. Isotype: IgG1. Applications: WB. UniProt Accession #: O14684. Origin: Animal/Mouse.