35 products were found matching "K15729"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PTGES. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PTGES. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PTGES. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PTGES. Next,...

Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 (Cay-17020) to PGE2 (Cay-14010). PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal...

Prostaglandin E2 (PGE2) inhibitor 3 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1, IC50 = 0.2 µM). It is selective for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH) in cell-free assays at 10 µM. PGE2 inhibitor 3 inhibits IL-1beta-induced production of PGE2...

UT-11 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It inhibits PGE2 production in both SK-N-AS human neuroblastoma and BV-2 mouse microglial cells (IC50s = 0.1 and 2 µM, respectively). UT-11 (10 mg/kg, i.p.) reduces LPS-induced increases in a variety of cytokines, including chemokine (C-C...

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 into the biologically active PGE2. Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. CAY10678 is a benzoimidazole that potently inhibits human and rat...

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig...

Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of...

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2, Cay-17020) into the biologically active PGE2 (Cay-14010). Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. PF-9184 is a potent inhibitor...

Prostaglandin E2 (PGE2, Cay-14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased...

PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1, IC50 = 3 nM). It is selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values greater than 50 µM, as well as COX-2 in fetal fibroblasts (IC50 = >10 µM). PF-4693627 inhibits...

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH2 (Cay-17020) into the biologically active PGE2 (Cay-14010). Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1beta, and TNF-alpha. AF3485 is a selective 3-aminocarbazole inhibitor...