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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A304-322A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A304-322A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: As a component of the trimeric and tetrameric DNA polymerase delta complexes... more
Product information "Anti-PolD2"
Protein function: As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol- delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). [The UniProt Consortium]
Keywords: | Anti-POLD2, Anti-DNA polymerase delta subunit 2, Anti-DNA polymerase delta subunit p50 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A304-322A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: rabbit, orangutan, rhesus monkey, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon, thirteen-lined ground squirrel, chinese tree shrew) |
Immunogen: | synthetic peptide. The epitope recognized by A304-322A-T maps to a region between residue 419 to 469 of human Polymerase (DNA directed), Delta 2, Accessory Subunit using the numbering given in entry NP_001120690.1 (GeneID 5425). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K02328 | Matching products |
UniProt ID : | P49005 | Matching products |
Gene ID | GeneID 5425 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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