Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P4258-03G.100 | 100 tests | - | - |
3 - 19 business days* |
912.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of... more
Product information "Anti-Platelet Derived Growth Factor Receptor, Type A (PDGFRa) (APC)"
PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF Ralpha binds all three PDGF isoforms with high affinity, PDGF Rb binds PDGF-BB and AB, but not PDGF-AA. Both PDGF Ra and PDGF Rb are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Only PDGF Ra is expressed in oligodendrocyte progenitor cells, mesothelial cell and liver endothelial cells. Soluble PDGF Ra has been detected in cell conditioned medium and human plasma. Recombinant soluble PDGF Ra binds PDGF with high affinity and is a potent PDGF antagonist (Heldin, C. H. and L. Claesson-Welsh, 1994, in Guidebook to Cytokines and Their Receptors, N. A. Nicola, editor, Oxford University Press, New York, New York, pp. 202-208). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: Use 10ul per 1x10e5 Fc-blocked cells or 50ul of packed whole blood, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid for 12 months. Dilute only pror to immediate use. APC conjugates are sensitive to light.
Supplier: | United States Biological |
Supplier-Nr: | P4258-03G |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 7H37 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human PDGF Ra. |
Format: | Purified |
Database Information
KEGG ID : | K04363 | Matching products |
UniProt ID : | P16234 | Matching products |
Gene ID | GeneID 5156 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed