Anti-PINK1, clone S4-15, Biotin Conjugated

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
200-306-W64	100 µg		-	-	6 - 10 business days*		713.00€

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Anti-PINK1 Antibody was purified from concentrated tissue culture supernate by Protein G... more

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Product information "Anti-PINK1, clone S4-15, Biotin Conjugated"

Anti-PINK1 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests that it is 82% identical to rat, 81% identical to mouse and >30% identical to DMPK. Protein function: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582). [The UniProt Consortium]

Keywords:	Anti-BRPK, Anti-PINK1, Anti-PTEN-induced putative kinase protein 1, Anti-Serine/threonine-protein kinase PINK1, mitochondrial
Supplier:	Rockland Immunochemicals
Supplier-Nr:	200-306-W64

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Monoclonal
Clone:	S4-15
Conjugate:	Biotin
Host:	Mouse
Species reactivity:	human, rat, mouse
Immunogen:	Fusion protein containing amino acids 112-496 of human PINK1.
Format:	Purified