Anti-PINK1, clone S4-15

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG22358.50	50 µg		-	-	6 - 14 business days*		520.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Protects against mitochondrial dysfunction during cellular stress by... more

Close menu

Product information "Anti-PINK1, clone S4-15"

Protein function: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). [The UniProt Consortium]

Keywords:	Anti-BRPK, Anti-PINK1, Anti-PTEN-induced putative kinase protein 1, Anti-Serine/threonine-protein kinase PINK1, mitochondrial
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG22358

Properties

Application:	WB, ICC, IF
Antibody Type:	Monoclonal
Clone:	S4-15
Conjugate:	No
Host:	Mouse
Species reactivity:	human, rat (Expected: mouse)
Immunogen:	Fusion protein around aa. 112-496 (cytoplasmic C-terminus) of Human PINK1. 82% identical to Rat and 81% identical to Mouse. > 30% identity with DMPK
MW:	50 kD
Format:	Purified