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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1511-0.1 | 100 µg | - |
3 - 11 business days* |
654.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PDE8a (high affinity cAMP-specific and IBMX-insensitive 3´,5´-cyclic phosphodiesterase 8 A) is a... more
Product information "Anti-PDE8a Monoclonal Antibody (Clone:EM-52)"
PDE8a (high affinity cAMP-specific and IBMX-insensitive 3´,5´-cyclic phosphodiesterase 8 A) is a cyclic nucleotide phosphodiesterase, which hydrolyzes cAMP, an important regulator and mediator of multiple cellular responses to extracellular signals. It is expressed in a wide variety of tissues including testis, ovary, small intestine, and colon. It is not expressed e.g. in thymus. PDE8a is composed of C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser- 259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). [The UniProt Consortium]
Keywords: | Anti-PDE8A, Anti-High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, Anti-PDE8a Monoclonal Antibody (Clone:EM-52) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1511 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | EM-52 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human PDE8a |
Format: | Affinity Purified |
Database Information
KEGG ID : | K18437 | Matching products |
UniProt ID : | O60658 | Matching products |
Gene ID | GeneID 5151 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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