Anti-PDE2A

alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,similarity:Contains 2 GAF domains.,subunit:Homodimer.,tissue specificity:Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas., Protein function: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9210593, PubMed:29392776, PubMed:15938621). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: [Isoform PDE2A3]: Cell membrane , Lipid-anchor ., [Isoform PDE2A2]: Mitochondrion matrix . Mitochondrion inner membrane . Mitochondrion outer membrane ., [Isoform PDE2A1]: Cytoplasm ., [Isoform 5]: Mitochondrion .