21 products were found matching "K18283"!

Active human PDE2A1 (GenBank Accession No. NM_002599), full length, with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Human PDE2A (GenBank Accession No. NM_002599), amino-acids 2-941, with N-terminal FLAG tag, MW=106 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Assay conditions: 10 mM Tris-HCl, pH 7.4, 10 mM Mg

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. [The UniProt Consortium]

Murine PDE2A, variant 1 (GenBank Accession No. NM_001143848), a.a 2-939 (end), with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Murine PDE2A, variant 2 (GenBank Accession No. NM_001008548), a.a 2-935, with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Murine PDE2A, variant 4 (GenBank Accession No. NM_001243757), a.a. 2-939 (end), with N-terminal GST tag, MW=132 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Rat PDE2A (GenBank Accession No. NM_00143847), full length, with N-terminal His-GST tag, MW=133 kDa, expressed in a Baculovirus infected Sf9 cell expression system

The PDE2A Assay Kit is designed for identification of PDE2A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE2A to the binding agent. PDE2A plays an important role in dynamic regulation of cAMP signaling in the cardiovascular...

The PDE2A Assay Kit is designed for identification of PDE2A inhibitors using fluorescence polarization.The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE2A to the binding agent. PDE2A catalyzes the hydrolysis of the phosphodiester bond in dye-labeled cyclic adenosine...

Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right...

The Mouse PDE2A Assay Kit is designed for identification of inhibitors of Mouse PDE2A using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by Mouse PDE2A to the binding agent. The key to the Mouse PDE2A Assay Kit is the specific binding agent. Using...

PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor (IC50 = 1.6 nM). It is greater than 2000-fold selective for PDE2A over a panel of ten additional PDEs. PF-05180999 increases striatal, cortical, and hippocampal cGMP levels in mice in a dose-dependent manner. In vivo, it inhibits disruption of low frequency...