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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB5945.50 | 50 µl | - |
9 - 20 business days* |
352.00€
|
|||
G-CAB5945.100 | 100 µl | - |
9 - 20 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins... more
Product information "Anti-PARP2"
Protein function: Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:32028527, PubMed:32939087). Mediates glutamate, aspartate or serine ADP- ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30321391). Serine ADP- ribosylation of proteins constitutes the primary form of ADP- ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins, HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034). [The UniProt Consortium]
Keywords: | Anti-ARTD2, Anti-PARP-2, Anti-ADPRT2, Anti-hPARP-2, Anti-ADPRT-2, Anti-pADPRT-2, Anti-Poly[ADP-ribose] synthase 2, Anti-Poly [ADP-ribose] polymerase 2, Anti-NAD(+) ADP-ribosyltransferase 2, Anti-DNA ADP-ribosyltransferase PARP2, PARP2 Rabbit mAb |
Supplier: | Assay Genie |
Supplier-Nr: | CAB5945 |
Properties
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A synthesized peptide derived from human PARP2 |
Database Information
KEGG ID : | K10798 | Matching products |
UniProt ID : | Q9UGN5 | Matching products |
Gene ID | GeneID 10038 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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