The following products have been found matching your search "K10798": 239

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Olaparib
Olaparib

Item number: Cay10621-5

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
Keywords: AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
Application: PARP1 / PARP2 inhibitor
CAS 763113-22-0
MW: 434.5 D
From 49.00€ *
Review
BMN 673
BMN 673

Item number: Cay19782-1

BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits...
Keywords: Talazoparib,...
Application: Antineoplastic, PARP inhibitor
CAS 1207456-01-6
MW: 380.4 D
From 69.00€ *
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Nicotinamide
Nicotinamide

Item number: LKT-N3310.50

Amide form of vitamin B3 required for production of NAD and NADP, GABA modulator.
Keywords: Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin PP, Vitamin B3, 3-Pyridinecarboxylic acid amide
Application: Protease inhibitor
CAS 98-92-0
MW: 122,12 D
From 61.00€ *
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NEW
6(5H)-Phenanthridinone
6(5H)-Phenanthridinone

Item number: Cay28730-1

6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (EC50s = 10.2 and 36.3 µM, respectively, in yeast cells expressing the human enzymes). It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells when used at a concentration of 50 µM....
Keywords: NSC 11021, NSC 40943, NSC 61083
Application: PARP1/2 inhibitor
CAS 1015-89-0
MW: 195.2 D
From 35.00€ *
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PARP-1 [ARTD1] (human) (rec.) (His) (high purity)
PARP-1 [ARTD1] (human) (rec.) (His) (high purity)

Item number: AG-40T-0011-C010

Human full-length PARP-1 [ARTD1] is fused to a MYC and His-tag. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol. PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of...
Keywords: ADPRT, ARTD1, PARP1, PARP-1, ADPRT 1, EC=2.4.2.30, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+)...
Application: Enzyme assays
Reactivity: Human
308.00€ *
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PARP1 assay kit
PARP1 assay kit

Item number: BPS-80551

The PARP1 Chemiluminescent Activity Assay kit is designed to measure PARP1 activity using purified PARP1 or PARP1 extracts. PARP1 is known to catalyze the NAD-dependent addition of poly, ADP-ribose, to histones. The PARP1 assay kit comes in a convenient 96-well format, with purified PARP1 enzyme, histone mixture,...
Keywords: ADPRT, PARP1, PARP-1, ADPRT 1, EC=2.4.2.30, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+)...
Application: PARP1 assays, HTS
665.00€ *
Review
PARP2 assay kit
PARP2 assay kit

Item number: BPS-80552

The PARP2 Chemiluminescent Activity Assay kit is designed to measure PARP2 activity using purified PARP2 or PARP2 extracts. PARP2 is known to catalyze the NAD-dependent addition of poly, ADP-ribose, to histones. The PARP2 assay kit comes in a convenient 96-well format, with purified PARP2 enzyme, histone mixture,...
Keywords: PARP-2, hPARP-2, ADPRT-2, pADPRT-2, EC=2.4.2.30, Poly[ADP-ribose] synthase 2, Poly [ADP-ribose] polymerase 2, NAD(+)...
Application: PARP2 assays, HTS
893.00€ *
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Iniparib
Iniparib

Item number: LKT-I5354.10

Cysteine adduct inducer, PARP-1 inhibitor.
Keywords: IND 71677, BSI-201
Application: Poly (ADP-ribose) polymerase 1 (PARP1) inhibitor
CAS 160003-66-7
MW: 292.03 D
From 107.00€ *
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DPQ
DPQ

Item number: Cay14450-1

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can...
Keywords: PARP Inhibitor III, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
Application: PARP inhibitor
CAS 129075-73-6
MW: 302.4 D
From 55.00€ *
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Olaparib
Olaparib

Item number: LKT-O4402.5

A potent orally active inhibitor of PARP (Poly(adenosine diphosphate-ribose) polymerase)-1 and PARP-2.
Keywords: AZD2281, KU-0059436
Application: Poly(adenosine diphosphate-ribose) polymerase inhibitor
CAS 763113-22-0
MW: 434,47 D
From 78.00€ *
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ABT-888 (hydrochloride)
ABT-888 (hydrochloride)

Item number: Cay11505-5

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...
Keywords: Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
Application: PARP1 / PARP2 inhibitor
CAS 912445-05-7
MW: 317.2 D
From 44.00€ *
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Anti-PARP1
Anti-PARP1

Item number: A301-375A

Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway...
Keywords: Anti-ADPRT, Anti-PARP1, Anti-ARTD1, Anti-PARP-1, Anti-ADPRT 1, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose]...
Application: WB, IP
Reactivity: Human
From 125.00€ *
Review
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