184 products were found matching "K10798"!

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...

BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits...

Active human PARP2 (GenBank Accession No. NM_005484), amino-acids 2-583 with N-terminal GST tag, MW = 92 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

A naturally occurring vitamin and a protease inhibitor. Topical nicotinamide has demonstrable preventive activity against photo carcinogenesis in mice by elevating skin nicotinamide-adenine dinucleotide (NAD) content. It also has protective effects against lung and pancreatic carcinogenesis. Niacinamide also...

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can...

Active human PARP3 (GenBank Accession No. NM_001003931), full length with N-terminal GST tag, MW = 87 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

A potent orally active inhibitor of PARP (Poly(adenosine diphosphate-ribose) polymerase)-1 and PARP-2.

AG-14361 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, Ki = 6.3 nM for the human enzyme). It inhibits PARP1 activity in permeabilized and intact SW620 cells (IC50s = 29 and 14 nM, respectively). AG-14361 (0.4 µM) potentiates the growth inhibitory effects of temozolomide (Cay-14163) in HCT116, A2480, and...

Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor, Inhibits peroxynitrite-induced cell necrosis, Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models, Provides cardioprotection by decreasing myocardial infarct size, Shows protective effects in models...

A potent inhibitor of both PARP-1 and PARP-2. It inhibits DNA repair and potentiates cytotoxic agents such as cisplatin and cyclophosphamide.

Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is...