The following products have been found matching your search "K10798": 232

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Olaparib
Olaparib

Item number: Cay10621-25

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
Keywords: AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
Application: PARP1 / PARP2 inhibitor
CAS 763113-22-0
MW: 434.5 D
From 49.00€ *
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PARP1 assay kit
PARP1 assay kit

Item number: BPS-80551

The PARP1 Chemiluminescent Activity Assay kit is designed to measure PARP1 activity using purified PARP1 or PARP1 extracts. PARP1 is known to catalyze the NAD-dependent addition of poly, ADP-ribose, to histones. The PARP1 assay kit comes in a convenient 96-well format, with purified PARP1 enzyme, histone mixture,...
Keywords: ADPRT, PARP1, PARP-1, ADPRT 1, EC=2.4.2.30, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+)...
Application: PARP1 assays, HTS
693.00€ *
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PARP2 assay kit
PARP2 assay kit

Item number: BPS-80552

The PARP2 Chemiluminescent Activity Assay kit is designed to measure PARP2 activity using purified PARP2 or PARP2 extracts. PARP2 is known to catalyze the NAD-dependent addition of poly, ADP-ribose, to histones. The PARP2 assay kit comes in a convenient 96-well format, with purified PARP2 enzyme, histone mixture,...
Keywords: PARP-2, hPARP-2, ADPRT-2, pADPRT-2, EC=2.4.2.30, Poly[ADP-ribose] synthase 2, Poly [ADP-ribose] polymerase 2, NAD(+)...
Application: PARP2 assays, HTS
930.00€ *
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BMN 673
BMN 673

Item number: Cay19782-1

BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits...
Keywords: Talazoparib,...
Application: Antineoplastic, PARP inhibitor
CAS 1207456-01-6
MW: 380.4 D
From 69.00€ *
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PARP2, active human recombinant protein
PARP2, active human recombinant protein

Item number: BPS-80502

Active human PARP2 (GenBank Accession No. NM_005484), amino-acids 2-583 with N-terminal GST tag, MW = 92 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Keywords: PARP-2, hPARP-2, ADPRT-2, pADPRT-2, EC=2.4.2.30, Poly[ADP-ribose] synthase 2, Poly [ADP-ribose] polymerase 2, NAD(+)...
Application: Enzyme kinetics, inhibitor screening
MW: 92 kD
618.00€ *
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PARP-1 [ARTD1] (human) (rec.) (His) (high purity)
PARP-1 [ARTD1] (human) (rec.) (His) (high purity)

Item number: AG-40T-0011-C010

Human full-length PARP-1 [ARTD1] is fused to a MYC and His-tag. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol. PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of...
Keywords: ADPRT, ARTD1, PARP1, PARP-1, ADPRT 1, EC=2.4.2.30, Poly[ADP-ribose] synthase 1, Poly [ADP-ribose] polymerase 1, NAD(+)...
Application: Enzyme assays
Reactivity: Human
308.00€ *
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ABT-888 (hydrochloride)
ABT-888 (hydrochloride)

Item number: Cay11505-5

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...
Keywords: Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
Application: PARP1 / PARP2 inhibitor
CAS 912445-05-7
MW: 317.2 D
From 44.00€ *
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A-966492
A-966492

Item number: Cay26378-1

A-966492 is a dual inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (Kis = 1 and 1.5 nM, respectively). It reduces tumor growth by 46 and 92% in an MX-1 mouse xenograft model when administered at doses of 100 and 200 mg/kg per day, respectively. A-966492 also reduces tumor growth in a B16/F10 murine...
Keywords: 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide
Application: PARP1 / PARP2 dual inhibitor
CAS 934162-61-5
MW: 324.4 D
From 32.00€ *
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CAY10749
CAY10749

Item number: Cay30058-1

CAY10749 is a dual inhibitor of poly(ADP-ribose) polymerase (PARP) and PI3K (IC50s = 6.03, 3.63, 5.62, and 7.41 nM for PARP1, PARP2, PI3Kalpha, and PI3Kdelta, respectively). It is selective for these enzymes over PI3Kbeta and PI3Kgamma (IC50s = 288.4 and 831.76 nM, respectively), as well as a panel of 374 additional...
Keywords: 4-[[3-[[2-[6-amino-4-(trifluoromethyl)-3-pyridinyl]-5,8-dihydro-4-(4-morpholinyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]carbonyl]...
Application: PARP / PI3K dual inhibitor
CAS 2337386-47-5
MW: 660.6 D
From 124.00€ *
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m-Methoxybenzamide
m-Methoxybenzamide

Item number: Cay30451-10

m-Methoxybenzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP, Ki = m-Methoxybenzamide (100, 200, and 300 mg/kg) increases the pain threshold in the paw pinch test in rats.
Keywords: m-Anisamide, meta-Methoxybenzamide, NSC 209527, NSC 28589, 3-methoxy-benzamide
Application: PARP inhibitor
CAS 5813-86-5
MW: 151.2 D
From 62.00€ *
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AZ9482
AZ9482

Item number: Cay30292-1

AZ9482 is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50s = 1, 1, 46, 640, 9, and 160 nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively). It induces centrosome declustering (EC50 = 50 = 3 nM).
Keywords: 2-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinecarbonitrile
Application: PARP inhibitor
CAS 1825345-33-2
MW: 450.5 D
From 69.00€ *
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DPQ
DPQ

Item number: Cay14450-1

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can...
Keywords: PARP Inhibitor III, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
Application: PARP inhibitor
CAS 129075-73-6
MW: 302.4 D
From 55.00€ *
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