Anti-PARG

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A305-405A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A305-405A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and... more

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Product information "Anti-PARG"

Protein function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699). Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR- dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). [The UniProt Consortium]

Keywords:	Anti-PARG, EC=3.2.1.143, Anti-Poly(ADP-ribose) glycohydrolase
Supplier:	Bethyl Laboratories
Supplier-Nr:	A305-405A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	synthetic peptide. The epitope recognized by A305-405A-T maps to a region between residue 250 to 300 of human Poly using the numbering given in entry Q86W56.1 (GeneID 8505).
Format:	Antigen Affinity Purified