42 products were found matching "K07759"!

The Enzolution(R) PARG Assay System is intended for use with the Transcreener(R) ADPR FP Assay Kit (Part #3030) to measure enzymatic activity for PARG (poly(ADP-ribose) glycohydrolase). PARG produces ADPR from the breakdown of poly(ADP-ribose) (polyADPR). It plays an important role in DNA damage repair and has been...

Active, full-length (aa 1-976), human poly(ADP-Ribose) glycohydrolase (PARG) enzyme, C-terminal 6xHis-tagged protein expressed and purified from Baculovirus-infected insect cells. The enzyme has been thoroughly validated with Transcreener ADPR Activity Assays. For specific activity, please refer to the Certificate...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PARG antibody detects Poly(ADP-ribose) glycohydrolase, encoded by the PARG gene on chromosome 10q11.23. PARG antibody is widely used in DNA damage response, chromatin remodeling, and cancer biology research. PARG is the main enzyme responsible...

White to off-white solid. Soluble in DMSO, methanol or acetonitrile. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies, Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>,30µ,M)....

Protein function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699). Required for...

Protein function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699). Required for...

Protein function: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:21892188, PubMed:23102699, PubMed:23474714). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-...

Protein function: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:21892188, PubMed:23102699, PubMed:23474714). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-...

PDD00017273 is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM in an enzyme assay). It maintains persistence of nuclear PAR chains in HeLa cells induced by the DNA damaging agent methylmethanesulfonate (MMS, IC50 = 37 nM). PDD00017273, in combination with MMS, increases nuclear phosphorylated H2AX...

Protein function: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose) (PubMed:21892188, PubMed:23102699, PubMed:23474714). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as...

Protein function: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose) (PubMed:21892188, PubMed:23102699, PubMed:23474714). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as...

Recombinant human PARG (Poly(ADP-ribose) glycohydrolase), full length encompassing amino acids 2-976 (end). The construct contains an N-terminal His-Tag (6xHis). The recombinant protein was affinity purified.