Anti-PAF Acetylhydrolase (human)

Platelet-activating factor acetylhydrolase (PAF-AH) is a calcium-independent member of the phospholipase A2 (PLA2) family that hydrolyzes the acetyl group at the sn-2 position of PAF, a phospholipid mediator involved in a variety of biological activities. There are three types of PAF-AH: two intracellular forms, PAF-AH1 and PAF-AH2, which are ubiquitously expressed, and an extracellular form, lipoprotein-associated phospholipase A2 (Lp-PLA2), which is found in the plasma in association with LDL and HDL.. Unlike PAF-AH1, which is largely restricted to hydrolysis of PAF, PAF-AH2 and Lp-PLA2 exhibit broader substrate specificity, hydrolyzing phospholipids with oxidized or short sn-2 acyl chains in addition to PAF. PAF-AH1 has roles in neuronal development, protein trafficking, and spermatogenesis, and PAF-AH2 and Lp-PLA2 have a protective roles against oxidative stress and atherosclerosis, respectively. Cayman's PAF-acetylhydrolase (human) Polyclonal Antibody can be used for Western blot (WB) applications.Synonyms: Lp-PLA2, PAF-AH, Platelet-activating Factor Receptor Acetylhydrolase. Immunogen: Synthetic peptide corresponding to the C-terminal region of human PAF-AH. MW: 45.4 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. Cross Reactivity: (+) PAF-AH. UniProt Accession #: Q13093. Origin: Animal/Rabbit.