Anti-NR2B, clone S59-36

Anti-NR2B Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NR2B from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross-reactivity against NR2A. Cross-reactivity with NR2B from other sources has not been determined. Ion Channels research. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2 influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]