Anti-phospho-NMDA R2B (Ser1480)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
612-401-D93	100 µl		-	-	6 - 10 business days*		684.00€

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Anti-NMDA R2B pS1480 antibody is directed against phosphorylated NMDA receptor protein. The... more

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Product information "Anti-phospho-NMDA R2B (Ser1480)"

Anti-NMDA R2B pS1480 antibody is directed against phosphorylated NMDA receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The antibody is specific for NMDA receptor phosphorylated at S1480. Immunolabeling is blocked by ?-phosphatase treatment. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, chicken, human, mouse, non-human primates and Xenopus. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2 influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]

Keywords:	Anti-phospho-NR2B, Anti-phospho-GluN2B, Anti-phospho-Grin2b, Anti-phospho-NMDAR2B, Anti-phospho-Glutamate receptor ionotropic, NMDA 2B, Anti-phospho-N-methyl D-aspartate receptor subtype 2B, Anti-phospho-Glutamate [NMDA] receptor subunit epsilon-2
Supplier:	Rockland Immunochemicals
Supplier-Nr:	612-401-D93

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	rat
Immunogen:	synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1480.
Format:	Purified