Anti-Notch2, intracellular (human specific)

Anti-Notch2, intracellular (human specific)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
100-401-406	200 µl		-	-	6 - 10 business days*		684.00€

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Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1... more

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Product information "Anti-Notch2, intracellular (human specific)"

Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. [The UniProt Consortium]

Keywords:	Anti-NOTCH2
Supplier:	Rockland Immunochemicals
Supplier-Nr:	100-401-406

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rat, mouse)
Immunogen:	synthetic peptide corresponding to amino acids 2396-2409 of human Notch2 (the total protein is 2471 amino acids)
MW:	110 kD
Format:	Serum