Anti-Notch2

Anti-Notch2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-084A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-084A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-084A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1... more
Product information "Anti-Notch2"
Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (PubMed:25985737). [The UniProt Consortium]
Keywords: Anti-NOTCH2
Supplier: Bethyl Laboratories
Supplier-Nr: A302-084A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rhesus Monkey, Gorilla, Black-handed Spider Monkey, Crab-eating Macaque, Kloss's Gibbon, Northern White-cheeked Gibbon, Red-chested Mustached Tamarin)
Immunogen: synthetic peptide. The epitope recognized by A302-084A-T maps to a region between residue 2421 and 2471 of human neurogenic locus notch homolog protein 2 using the numbering given in entry NP_077719.2 (GeneID 4853).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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