Anti-NOTCH 2 (Cleaved N terminal) (Human specific)

Anti-NOTCH 2 (Cleaved N terminal) (Human specific)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
100-401-408S	25 µl		-	-	6 - 10 business days*		180.00€

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This antiserum is directed against human NOTCH 2. Based on sequences, we expect this antibody to... more

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Product information "Anti-NOTCH 2 (Cleaved N terminal) (Human specific)"

This antiserum is directed against human NOTCH 2. Based on sequences, we expect this antibody to react as well with rat and mouse NOTCH 2. Only one amino acid difference (conservative) occurs in mouse and rat. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form. Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. [The UniProt Consortium]

Keywords:	Anti-NOTCH2
Supplier:	Rockland Immunochemicals
Supplier-Nr:	100-401-408S

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	synthetic peptide corresponding to amino acid residues of human Notch 2 located near the N-terminal sequence of the cleaved N intracellular domain (NICD).
Format:	Antiserum