Anti-NMDAR2B

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The N-methyl-D-aspartate receptor 2B is also called GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse proteins, respectively. The gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Overexpression of NMDAR2B in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz. Protein function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. [The UniProt Consortium]