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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-39-2054-100 | 100 µg | - |
3 - 11 business days* |
801.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GRIN2A is also known as N-methyl-D-aspartate receptor channel, subunit epsilon-1(NMDAR2A). This... more
Product information "Anti-NMDAR2A"
GRIN2A is also known as N-methyl-D-aspartate receptor channel, subunit epsilon-1(NMDAR2A). This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. Protein function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition, channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. [The UniProt Consortium]
Keywords: | Anti-NR2A, Anti-hNR2A, Anti-GRIN2A, Anti-GluN2A, Anti-NMDAR2A, Anti-Glutamate receptor ionotropic, NMDA 2A, Anti-N-methyl D-aspartate receptor subtype 2A, Anti-Glutamate [NMDA] receptor subunit epsilon-1, Polyclonal Antibody to Anti-NMDAR2A Antibody |
Supplier: | Abeomics |
Supplier-Nr: | 39-2054 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A synthetic peptide corresponding to a sequence at the C-terminal of human NMDAR2A(1411-1427aa, YCSRDSRGHNDVYISEH), different from the mouse and rat sequences by one amino acid. |
Database Information
KEGG ID : | K05209 | Matching products |
UniProt ID : | Q12879 | Matching products |
Gene ID | GeneID 2903 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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