89 products were found matching "K05209"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. N-methyl-D-aspartate receptor channel, subunit epsilon-1 (NMDAR2A or NR2A) is a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and...

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 µM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (-)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been...

NMDA is a synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate. Signaling through the NMDA receptor influences both neuronal plasticity and neurotoxicity. Repetitive activation of NMDA synapses leads to long-term...

Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 µM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A)...

1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on...

DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5 (Cay-14539). Whereas D-AP5 is the active (-)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 µM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA...

Anti-NMDA R2A antibody is directed against NMDA R2A protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Expect reactivity with the following species based on 100% sequence homology: bovine, canine and mouse. Protein function: NMDA receptor subtype of...

Amantadine is an NMDA receptor antagonist with IC50 values of 0.93, 0.82, and 0.47 µM at -70 mV for NR1-1a/NR2A, NR1-1a/NR2B, and NR1-1a/NR2D subunit-containing recombinant receptors, respectively, expressed in HEK293 cells. It blocks the influenza A M2 proton channel (IC50 = 16 µM for the recombinant channel...

D-Cycloserine is an NMDA receptor (NMDAR) partial agonist with antibiotic activity. It selectively binds to the glycine binding site (Ki = 2.33 µM) over the glutamate binding site (Ki = >100 µM). D-Cycloserine modulates memory in a T-maze footshock test in CD-1 mice with optimal memory retention at doses of 10-30...

TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit (pIC50s = 6.8 and 95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH7.2) (1:40): 0.02 mg/ml, DMSO: 20 mg/ml. lambdamax: 232 nm. SMILES:...

Memantine-d6 is intended for use as an internal standard for the quantification of memantine (Cay-14184) by GC- or LC-MS. Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 µM. It reverses inhibition of dephosphorylation...