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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1304-0.1 | 100 µg | - |
3 - 11 business days* |
623.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in... more
Product information "Anti-Neurofilament heavy protein Monoclonal Antibody (Clone:NF-05)"
Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H rod is uniquely long (more than 600 amino acids) compared to other IF proteins and is highly charged (> 24 % Glu, > 25 % Lys), rich in proline (> 12 %) and improverished in cysteine, methionine and aromatic amino acids. Its most remarkable feature is a repetitive sequence that covers more than half its lenght and includes the sekvence motif Lys-Ser-Pro (KSP) greater than 40 times. Plasma neurofilament heavy chain level has been proposed as a marker of axonal injury and clinical use of its degeneration and loss has been suggested as a biomarker of several neurodegenerative diseases. Protein function: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. [The UniProt Consortium]
Keywords: | Anti-NEFH, Anti-NF-H, Anti-KIAA0845, Anti-200 kDa neurofilament protein, Anti-Neurofilament heavy polypeptide, Anti-Neurofilament triplet H protein, Anti-Neurofilament heavy protein Monoclonal Antibody (Clone:NF-05) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1304 |
Properties
Application: | WB, IHC (frozen), ELISA |
Antibody Type: | Monoclonal |
Clone: | NF-05 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, pig, rat |
Immunogen: | Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules |
Format: | Purified |
Database Information
KEGG ID : | K04574 | Matching products |
UniProt ID : | P12036 | Matching products |
Gene ID | GeneID 4744 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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