Anti-NCSTN / Nicastrin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40091.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that... more

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Product information "Anti-NCSTN / Nicastrin"

Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. [The UniProt Consortium]

Keywords:	Anti-NCSTN, Anti-KIAA0253, Anti-Nicastrin
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40091

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	mouse, rat
Immunogen:	Recombinant fusion protein corresponding to aa. 429-669 of Human NCSTN (NP_056146.1)
MW:	78 kD
Format:	Affinity Purified