Anti-Mouse IL-1 alpha NALE(TM) Purified (Clone: ALF-161)

IL-1 Alpha is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 Alpha and IL-1 Beta bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 Beta is a secreted cytokine, IL-1 Alpha is predominantly a cell-associated cytokine. The ALF-161 monoclonal antibody reacts with the precursor, secreted and membrane-associated forms of mouse IL-1 Alpha. The antibody is reported to be usable as the capture antibody in an ELISA assay and exhibits neutralization properties. Protein function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. [The UniProt Consortium]