Anti-MALT1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Mucosa-associated lymphoid tissue lymphoma translocation protein 1, also called MLT or Paracaspase, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al.(1999) and Akagi et al.(1999) mapped the gene to chromosome 18q21. Using mouse models, Ruland et al.(2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases. Protein function: Protease that enhances BCL10-induced activation of NF-kappa-B by mediating its cleavage (PubMed:11262391, PubMed:18264101). MALT1- dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). Also has ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). [The UniProt Consortium]