Anti-MADD

Anti-MADD
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-144A-T 10 µl (10 µg) -

6 - 10 business days*

131.00€
A302-144A 100 µl (100 µg) -

6 - 10 business days*

465.00€
 
Protein function: Plays a significant role in regulating cell proliferation, survival and death... more
Product information "Anti-MADD"
Protein function: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis), isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. [The UniProt Consortium]
Keywords: Anti-Rab3 GDP/GTP exchange factor, Anti-Insulinoma glucagonoma clone 20, Anti-MAP kinase-activating death domain protein, Anti-Differentially expressed in normal and neoplastic cells
Supplier: Bethyl Laboratories
Supplier-Nr: A302-144A

Properties

Application: IP, IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A302-144A-T maps to a region between residue 1597 and 1647 of human MAP-kinase activating death domain using the numbering given in entry NP_003673.3 (GeneID 8567).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q8WXG6 | Find alternatives
Gene ID GeneID 8567 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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