Anti-MADD

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG54327.50	50 µg		-	-	6 - 14 business days*		608.00€

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Protein function: Plays a significant role in regulating cell proliferation, survival and death... more

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Product information "Anti-MADD"

Protein function: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis), isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. [The UniProt Consortium]

Keywords:	Anti-Rab3 GDP/GTP exchange factor, Anti-Insulinoma glucagonoma clone 20, Anti-MAP kinase-activating death domain protein, Anti-Differentially expressed in normal and neoplastic cells
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG54327

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Peptide corresponding to aa 1570-1588 of human MADD. This peptide sequence is identical to that of DENN and differs by one amino acid with rat GDP/GTP exchange protein RAB3-GEP
Format:	Affinity Purified