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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T... more
Product information "Anti-LCP2"
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. Protein function: Involved in T-cell antigen receptor mediated signaling. [The UniProt Consortium]
Keywords: | Anti-LCP2, Anti-SLP76, Anti-Lymphocyte cytosolic protein 2, Anti-SLP-76 tyrosine phosphoprotein, Anti-SH2 domain-containing leukocyte protein of 76 kDa, LCP2 Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-66090 |
Properties
Application: | IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant fusion protein of human LCP2 (NP_005556.1). |
Database Information
KEGG ID : | K07361 | Matching products |
UniProt ID : | Q13094 | Matching products |
Gene ID | GeneID 3937 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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