Anti-Lasu1/Ureb1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-836A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-836A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent... more

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Product information "Anti-Lasu1/Ureb1"

Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. [The UniProt Consortium]

Keywords:	Anti-Mule, Anti-LASU1, Anti-HUWE1, Anti-URE-B1, Anti-HectH9, Anti-ARF-BP1, Anti-HSPC272, Anti-KIAA0312, EC=2.3.2.26, Anti-URE-binding protein 1, Anti-ARF-binding protein 1, Anti-Large structure of UREB1, Anti-Mcl-1 ubiquitin ligase E3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-836A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Goat
Species reactivity:	human (Expected: dog, horse, rabbit, guinea pig_10141, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, european domestic ferret, naked mole rat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A303-836A-T maps to a region between residue 2250 and 2300 of human HECT domain protein LASU1/Upstream Regulatory Element Binding Protein 1 using the numbering given in entry NP_113584.3 (GeneID 10075).
Format:	Antigen Affinity Purified