Anti-Lasu1/Ureb1 (IHC)

Anti-Lasu1/Ureb1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00439-T 10 µl (5+ slides) -

6 - 10 business days*

131.00€
IHC-00439 100 µl (50+ slides) -

6 - 10 business days*

493.00€
 
Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent... more
Product information "Anti-Lasu1/Ureb1 (IHC)"
Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. [The UniProt Consortium]
Keywords: Anti-Mule, Anti-LASU1, Anti-HUWE1, Anti-URE-B1, Anti-HectH9, Anti-ARF-BP1, Anti-HSPC272, Anti-KIAA0312, EC=2.3.2.26, Anti-URE-binding protein 1, Anti-ARF-binding protein 1, Anti-Large structure of UREB1, Anti-Mcl-1 ubiquitin ligase E3
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00439

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Panda, Orangutan, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00439 maps to a region between residues 1025 and 1075 of human Upstream Regulatory Element Binding Protein 1 using the numbering given in entry NP_113584.2 (GeneID 10075).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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