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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-45-1101-40 | 40 µg | - |
3 - 11 business days* |
499.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
LAG-3 (Lymphocyte activation gene-3), designated CD223, is a 70 kDa type I transmembrane protein... more
Product information "Anti-LAG3 (human) (Clone: LG.B5)"
LAG-3 (Lymphocyte activation gene-3), designated CD223, is a 70 kDa type I transmembrane protein that is a member of the immunoglobulin superfamily (IgSF). LAG-3 is expressed on activated CD4+ and CD8+ T cells, NK cells, and plasmacytoid dendritic cells (pDC), but not on resting T cells. LAG-3 on activated CD4+CD25+ Treg cells plays a role in their suppressive activity. LAG-3 limits the expansion of activated T cells and pDC in response to selected stimuli. In mice, deletion of LAG-3 and another negative regulator, PD-1, facilitates anti-cancer response but also blocks self-tolerance and increases susceptibility to autoimmune diseases. In humans, antibody-mediated down-regulation of LAG-3 and PD-1 allows more effective control of chronic malaria, while in NOD (non-obese diabetic) mice, deletion of LAG-3 alone accelerates diabetes. Human LAG3 Antibody (LG.B5), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with Recombinant human LAG3-Fc. Protein function: Involved in lymphocyte activation. Binds to HLA class-II antigens. [The UniProt Consortium]
Keywords: | Anti-FDC, Anti-LAG3, Anti-LAG-3, Anti-CD223, Anti-Protein FDC, Anti-Lymphocyte activation gene 3 protein, Mouse Monoclonal Antibody to Human LAG3 (Clone: LG.B5) |
Supplier: | Abeomics |
Supplier-Nr: | 45-1101 |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | LG.B5 |
Conjugate: | No |
Host: | Mouse |
Immunogen: | Recombinant human LAG3-Fc |
Format: | Purified |
Database Information
KEGG ID : | K06565 | Matching products |
UniProt ID : | P18627 | Matching products |
Gene ID | GeneID 3902 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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