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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-CAB12682.50 | 50 µl | - | - |
9 - 20 business days* |
352.00€
|
||
G-CAB12682.100 | 100 µl | - |
9 - 20 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
WB 1:1000 - 1:3000. Protein function: Tyrosine kinase that plays an essential role in regulation... more
Product information "Anti-ITK"
WB 1:1000 - 1:3000. Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3. [The UniProt Consortium]
Keywords: | Anti-ITK, Anti-EMT, Anti-Kinase EMT, EC=2.7.10.2, Anti-T-cell-specific kinase, Anti-Tyrosine-protein kinase Lyk, Anti-IL-2-inducible T-cell kinase, Anti-Tyrosine-protein kinase ITK/TSK, Anti-Interleukin-2-inducible T-cell kinase, ITK Polyclonal Antibody ( |
Supplier: | Assay Genie |
Supplier-Nr: | CAB12682 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Database Information
KEGG ID : | K07363 | Matching products |
UniProt ID : | Q08881 | Matching products |
Gene ID | GeneID 3702 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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