50 products were found matching "K07363"!

ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines.

PF-06465469 is a covalent inhibitor of IL-2-inducible T cell kinase (Itk, IC50 = 2 nM). It also inhibits Bruton's tyrosine kinase (BTK, IC50 = 2 nM). PF-06465469 inhibits Itk phosphorylation of phospholipase Cgamma (PLCgamma) induced by an anti-CD3 antibody in Jurkat cells (IC50 = 57 nM). It induces apoptosis in...

An Itk inhibitor (IC50 = 19 nM), selective for Itk over 18 other kinases (IC50s = >1,100 nM for all), inhibits IL-2 secretion from Jurkat T cells and isolated human PBMCs induced by antibodies targeting CD3 (IC50s = 0.25 and 0.39 µM, respectively), decreases serum levels of Il-2 and the lung infiltration of total...

Active recombinant human ITK (352-end) was expressed in Sf9 cells using an N-terminal GST tag. The gene accession number is NM_005546.

The ITK Kinase Assay Kit is designed to measure ITK kinase activity for screening and profiling applications using ADP-Glo(R) as a detection reagent.

Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation...

Active murine recombinant IL2-inducible T-cell kinase (ITK), also known as Lyk and TSK (GenBank Accession #NM_010583),a.a. 352-620(end) with N-terminal GST-tag, MW= 57 kDa, expressed in Sf9 cells via abaculovirus expression system.

Active rat recombinant IL2-inducible T-cell kinase (ITK), also known as Lyk and TSK (GenBank Accession #NM_010583),a.a. 352-620(end) with N-terminal GST-tag, MW= 57 kDa, expressed in Sf9 cells via abaculovirus expression system.

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: IL2-inducible T-cell kinase Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: IL2-inducible T-cell kinase Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation...

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. Protein function: Tyrosine kinase that plays an essential role in regulation...

Protein function: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation...