Anti-Interleukin 17 Receptor (IL-17R, CTLA8, IL-17RA, Interleukin-17 Receptor A) (PE)

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine. IL-17 binds to IL-17 receptor (IL-17 R), which shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested. The hIL-17 R gene was localized to chromosome 22. Human IL-17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293aa extracellular domain, a 21aa carboxy-proximal transmembrane domain, and a 525aa cytoplasmic tail. The aa sequence of hIL-17 R is 69% identical to the mIL-17 R. The signaling events of IL-17 include activation of NF-kB and JNK, and require TNF receptor-associated factor 6 (TRAF6). Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 10ul to label 1x10e5 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.