Anti-IL6ST/CD130

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-929A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-929A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF,... more

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Product information "Anti-IL6ST/CD130"

Protein function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. [The UniProt Consortium]

Keywords:	Anti-IL6ST, Anti-CD130, Anti-gp130, Anti-CDw130, Anti-IL-6RB, Anti-IL-6R-beta, Anti-IL-6R subunit beta, Anti-Membrane glycoprotein 130, Anti-IL-6 receptor subunit beta, Anti-Interleukin-6 signal transducer, Anti-Oncostatin-M receptor subunit alpha
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-929A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat)
Immunogen:	synthetic peptide. The epitope recognized by A304-929A-T maps to a region between residue 868 to 918 of human Interleukin-6 receptor subunit beta using the numbering given in entry P40189.2 (GeneID 3572).
Format:	Antigen Affinity Purified