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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-506-W89 | 100 µg | - | - |
6 - 10 business days* |
713.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-HSF1 Antibody was purified from concentrated tissue culture supernate by Protein G... more
Product information "Anti-HSF1 Monclonal, clone 4B4, Biotin Conjugated"
Anti-HSF1 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. HSF1, or heat shock factor 1, belongs to a family of Heat Shock transcription factors that activate the transcription of genes encoding products required for protein folding, processing, targeting, degradation, and function (2). The up-regulation of HSP (heat shock proteins) expression by stressors is achieved at the level of transcription through a heat shock element (HSE) and a transcription factor (HSF) (3, 4, 5). Most HSFs have highly conserved amino acid sequences. On all HSFs there is a DNA binding domain at the N-terminus. Hydrophobic repeats located adjacent to this binding domain are essential for the formation of active trimers. Towards the C-terminal region another short hydrophobic repeat exists, and is thought to be necessary for suppression of trimerization (6). There are two main heat shock factors, 1 and 2. Mouse HSF1 exists as two isoforms, however in higher eukaryotes HSF1 is found in a diffuse cytoplasmic and nuclear distribution in un-stressed cells. Once exposed to a multitude of stressors, it localizes to discrete nuclear granules within seconds. As it recovers from stress, HSF1 dissipates from these granules to a diffuse nuceloplasmic distribution. HSF2 on the other hand is similar to mouse HSF1, as it exists as two isoforms, the alpha form being more transcriptionally active than the smaller beta form (7, 8). Various experiments have suggested that HFS2 may have roles in differentiation and development (9, 10, 11). Anti-HSF1 Antibody is ideal for research in Genetics, Transcription, Cell Signaling and pathways including ERK and MAPK.
Keywords: | Anti-Hsf1, Anti-HSF 1, Anti-HSTF 1, Anti-Heat shock factor protein 1, Anti-Heat shock transcription factor 1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-506-W89 |
Properties
Application: | ELISA, EMSA, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 4B4 |
Conjugate: | Biotin |
Host: | Rat |
Species reactivity: | human, mouse, rat, bovine, guinea pig, hamster, monkey, rabbit |
Immunogen: | Purified recombinant mouse HSF1 protein, epitope mapping to amino acids 425-439. |
Format: | Purified |
Database Information
KEGG ID : | K09414 | Matching products |
UniProt ID : | P38532 | Matching products |
Gene ID | GeneID 15499 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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