Anti-Histone H4K16Ac Monoclonal Antibody (RM204)

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Acetylation of histone H4 at lysine 16 (H4K16Ac) is associated with transcriptional activation. Cellular H4K16Ac levels are decreased in Jurkat and HL-60 leukemia cells compared with normal human lymphocytes, and tumor H4K16Ac levels are reduced in patients with lymphoma or colorectal cancer. Cayman's Histone H4K16Ac Monoclonal Antibody (RM204) can be used for ELISA, multiplex-based assay, and Western blot (WB) applications.Synonyms: Acetylated Histone H4 Lysine 16. Immunogen: Peptide corresponding to H4K16Ac. Clone Designation: RM204. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, multiplex-based assays, WB. Cross Reactivity: (+) H4K16Ac, (-) Unmodified H4K16, (-) H4K5Ac, (-) H4K8Ac, (-) H4K12Ac, (-) H4K20Ac, (-) H4K31Ac, (-) H4K91Ac.