Anti-Histone H4K12Ac Monoclonal Antibody (RM202)

Anti-Histone H4K12Ac Monoclonal Antibody (RM202)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay32162-100 100 µg -

6 - 10 business days*

634.00€
 
Histone H4 is one of four core histone proteins that are involved in the organization of DNA into... more
Product information "Anti-Histone H4K12Ac Monoclonal Antibody (RM202)"
Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that can influence chromatin structure and regulate gene transcription. Acetylation of histone H4 at lysine 12 (H4K12Ac) is associated with chromatin relaxation and gene transcription. Levels of H4K12Ac are elevated in two transgenic mouse models of Alzheimer's disease, as well as in monocytes isolated from patients with mild cognitive impairment and Alzheimer's disease. H4K12Ac levels are also increased in response to chronic alcohol exposure and positively correlate with the release of the pro-inflammatory cytokine chemokine (C-C motif) ligand 8 (CCL8) in monocyte-derived dendritic cells. Cayman's H4K12Ac Monoclonal Antibody (RM202) can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.Synonyms: Acetylated Histone H4 Lysine 12. Immunogen: Peptide corresponding to H4K12Ac. Clone Designation: RM202. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ChIP, ELISA, ICC, multiplex-based assays, WB. Cross Reactivity: (+) H4K12Ac, (-) Unmodified H4K12, (-) H4K5Ac, (-) H4K8Ac, (-) H4K16Ac, (-) H4K20Ac, (-) H4K31Ac, (-) H4K91Ac.
Keywords: Acetylated Histone H4 Lysine 12
Supplier: Cayman Chemical
Supplier-Nr: 32162

Properties

Application: ChIP, ELISA, ICC, multiplex, WB
Antibody Type: Monoclonal
Clone: RM202
Conjugate: No
Host: Rabbit
Species reactivity: vertebrates
Immunogen: Peptide corresponding to H4K12Ac
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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