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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker...

Histones are a family of basic proteins that form the core of the nucleosome - the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Histone proteins not only serve to compact chromosomal DNA but also...

The amino-terminal tails of core histones undergo lysine methylation in multiple sites, termed as "histone code" or "epigenetic code". Lysine methylation in core histones is a major determinant for the formation of active and inactive regions of the genome and therefore plays vital roles in multiple cellular events....

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Histone H4 (mono methyl K20) antibody detects Histone H4 monomethylated at lysine 20, encoded by the HIST1H4A gene. Histone H4 is a core nucleosomal protein that organizes chromatin and regulates...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The Histone H4 antibody targets Histone H4, one of the four core histones encoded by multiple HIST1H4 genes. Histone H4 forms part of the nucleosome core along with histones H2A, H2B, and H3, serving as a fundamental structural unit of...

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H4 undergoes many...

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that...

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of post-translational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that...

Histone H4 is one of four core histone proteins that are involved in the organization of DNA into chromatin. Histones are globular proteins with unstructured N-terminal tails and are subject to a variety of posttranslational modifications, such as methylation, acetylation, phosphorylation, and citrullination, that...

Human Histone 4 (HIST2H4A) (GenBank Accession No. NM_003548), a.a. 2-104(end) with N-terminal His-tag, MW = 12.1 kDa, expressed in an E. coli expression system. A suitable substrate for histone methyltransferases.

Human Histone 4 (HIST2H4A) (GenBank Accession No. NM_003548), a.a. 2-104(end) with N-terminal His-tag, MW = 12.1 kDa, expressed in an E. coli expression system. Application: A suitable substrate for histone methyltransferases.

Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA...