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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2544SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes an epitope on the extracellular... more
Product information "Anti-GnRH Receptor (GNRHR), clone F1G4 or GNRH03"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations. Protein function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. [The UniProt Consortium]
Keywords: | Anti-GRHR, Anti-GNRHR, Anti-GnRH-R, Anti-GnRH receptor, Anti-Gonadotropin-releasing hormone receptor, GnRH Receptor Antibody (GNRHR) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2544SAF |
Properties
Application: | FC, IF, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | F1G4|GNRH03 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, rat (Expected: swine, rabbit) |
Immunogen: | A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from human GnRH receptor. |
Format: | Purified |
Database Information
KEGG ID : | K04280 | Matching products |
UniProt ID : | P30968 | Matching products |
Gene ID | GeneID 2798 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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