Anti-Glucocorticoid Receptor, clone 8E9

Anti-Glucocorticoid Receptor, clone 8E9
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG22425.100 100 µg - -

6 - 14 business days*

571.00€
 
Protein function: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action:... more
Product information "Anti-Glucocorticoid Receptor, clone 8E9"
Protein function: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. [The UniProt Consortium]
Keywords: Anti-GR, Anti-GRL, Anti-NR3C1, Anti-Glucocorticoid receptor, Anti-Nuclear receptor subfamily 3 group C member 1
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG22425

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 8E9
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: 26 amino acid peptide corresponding to residues 150-176 of human GCR linked to human thyroglobulin
MW: 97 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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